Dr. Kun Chen published article on Aquatic Toxicology with the title of "Obesogenic and developmental effects of TBT on the gene expression of juvenile Japanese medaka (Oryzias latipes)".
Abstract: The widely used antifoulant tributyltin chloride (TBT) is highly toxic to aquatic organisms. In the present study, four-week-old Japanese medaka (Oryzias latipes) juveniles were orally exposed to TBT at 1 and 10 ng/g bw/d for 1, 2, and 4 weeks, respectively. Half of the tested medaka juveniles showed bone morphology alterations in both 1 and 10 ng/g bw/d TBT 4-week exposure groups. Nile Red (NR) staining showed that the juveniles exposed to 1 ng/g bw/d TBT for 2 and 4 weeks had significantly enlarged adipocyte areas. The mRNA-Seq analysis indicated that 1 ng/g bw/d TBT exposure for 2 weeks affected bone morphology through developmental processes. The GO and KEGG analyses suggested that the adipogenic effect of TBT observed in this study may be induced by metabolic processes, oxidative phosphorylation, and fatty acid degradation and metabolism pathways. Therefore, both morphological observation and mRNA-Seq analysis showed obesogenic effects and developmental toxicity of TBT to juvenile Japanese medaka.
Acknowledgements: This study was partly funded by the cooperative research program of the Institute of Nature and Environmental Technology, Kanazawa University (Accept No.5 in 2015), the National Natural Science Foundation of China (Grant No. 32071623), the Jiangsu Provincial DoubleInnovation Program (Grant No. 1711370013), and the Jiangsu University High-Level Construction Foundation (Grant No. 4111370000).
DOI: https://doi.org/10.1016/j.aquatox.2021.105907
